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Multiple Training Modalities for Patients with Alzheimer's Disease

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November 21, 2016 -
A pilot study from Taiwan investigated the effects of multiple training modalities on cognition, neuropsychiatric symptoms, caregivers' burden, and quality of life in patients with Alzheimer's disease (AD).

This study was conducted in 24 patients with AD aged 65 years or older with a Clinical Dementia Rating (CDR) score of 0.5-1. Fourteen of the patients were assigned to receive multiple training modalities (1 hour for each training: Tai Chi, calligraphy, and drawing) over a 6-week period in either the experimental group and 10 were assigned to the comparison group. A series of neuropsychological tests - namely the Traditional Chinese version Mini-Mental Status Examination, Cognitive Assessment Screening Instrument (CASI), Neuropsychiatric Inventory and the Neuropsychiatric Inventory Caregiver Distress Scale, and the Clinical Dementia Rating Sum of Boxes scale - were conducted at the baseline and after the intervention. The World Health Organization Quality of Life-BREF (WHOQOL-BREF) and Zarit Caregiver Burden Scale were used to assess the quality of life and caregivers' burden, respectively. Independent sample t-test and paired sample t-test were used to analyze the data.

After the program, the experimental group reported higher scores in the orientation domain of CASI and in the psychiatry domain of WHOQOL-BREF compared with the comparison group. Caregivers' distress was significantly decreased in the experimental group but not in the comparison group.

The findings were published by the journal Neuropsychiatric Disease and Treatment in November, 2016.


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